ORLANDO, FL (UroToday) - All urologists have seen sepsis following transrectal biopsy of the prostate.

This group's report adds to a growing body of literature suggesting that we are going to see this more often.

Gerboc and colleagues reviewed antibiotic sensitivity data for Escherichia Coli culture isolates at their institution from 2002 to 2005. 41% of culture isolates were resistant to fluoroquinolones in 2005, a very impressive increase from a mere 22% in 2002. The risk of infection following PnBx from most large series is still below 5%; nevertheless, as fluoroquinolone resistance rises, appropriate counseling of patients prior to prostate biopsy regarding this growing risk will become more important.

Investigation of protocols that involve intravenous administration of another antibiotic class in the procedure room immediately prior to biopsy may be necessary.

Presented by Jason Gerboc, MD, Michael J Metro, MD, Phillip C Ginsberg, MD, and Richard C Harkaway, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday Contributing Editor Alexander Kutikov, MD

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