UroToday - The optimal method of timely and appropriate diagnosis of prostate cancer remains a matter of considerable debate. While some contend that screening efforts identify a large number of men with clinically irrelevant cancer, prostate cancer remains a major health concern in the U.S. Needle biopsy of the prostate gland remains the primary means of identifying cancer and assessing its biologic potential via histologic grading. Our study demonstrates that the number of cores removed increased significantly over the past decade. This trend is likely associated with the increased detection of prostate cancer, contributing to the dilemma of prostate cancer over-detection and over-treatment. The increased number of biopsies may allow more accurate grading of the tumors, but may also artificially reduce the perceived severity of the cancer by lowering the percent of cores involved with cancer, a component of several risk-stratification models. These data underscore the need for better methods of:

1. identifying men who need to undergo prostate biopsy
2. localizing areas of tumor within the gland, and
3. assessing which cancers will progress to clinical significance over time.

Maxwell V. Meng, MD, as part of Beyond the Abstract on UroToday. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.

Link to Full Abstract

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